Contact Us

Give us a call or drop by anytime, we endeavor to answer all inquiries within 24 hours.

map

Find us

PO Box 16122 Collins Street West Victoria, Australia

Email us

info@domain.com / example@domain.com

Phone support

Phone: + (066) 0760 0260 / + (057) 0760 0560

Explore. Innovate. Inspire.

Advancing the Understanding of the Epigenetic Differences between Women and Men, Stem Cells, Development, and Rejuvenation

Our Vision

We are driven by curiosity and a passion for discovery. Our lab focuses on understanding how genes are turned on and off and how this leads to changes in cell identity during development and enables the reprogramming of adult cells to a younger state. We also study how these mechanisms differ between males and females and pave the way for understanding diseases and personalized medicine.

Our Impact

We invent and apply cutting-edge technologies to study chromatin dynamics and single cell epigenomics, transcriptomics, and secretomics; we partner with leading scientists at UCLA and worldwide to push the boundaries of biomedical research; and we contribute to groundbreaking advancements in stem cell biology, developmental biology, epigenetics, reprogramming and X-chromosome biology.

WHAT WE DO

Our Focus Areas

Resilience of Water Systems

Enhancing the ability of water infrastructure and ecosystems to withstand and recover from disturbances, ensuring sustainable water management in the face of changing environmental conditions.

Read More
Urban Water Management

Implementing sustainable and integrated strategies to address the complex challenges of water supply, distribution, and wastewater treatment in urban environments.

Read More
Water Quality and Pollution

Seeking to understand, monitor, and mitigate the impact of contaminants on aquatic ecosystems, safeguarding both environmental health and human well-being.

Read More

Our Research

Engineering Cell Fate

ENGINEERING CELL FATE

We are exploring how somatic cells can be converted into induced pluripotent stem cells (iPSCs), paving the way for regenerative and rejuvenation medicine. We dissect molecular mechanisms of gene regulation by transcription factors and the impact of genetic variation on gene regulatory networks.

Learn More

X-Chromosome Regulation

X-CHROMOSOME REGULATION

Females have two X chromosomes (XX), whereas males have one X and one Y chromosome (XY). We are exploring how gene expression on the X chromosomes is regulated in females to ensure balance with males. We also dissect how these female-specific mechanisms impact female-biased diseases such as auto-immunity. We aim to pioneer new insights into the mechanisms underlying X-chromosome dosage compensation in females to address these conditions.

Learn More

Modelling Human Development

MODELLING HUMAN DEVELOPMENT

We develop and utilize stem cell-based models to explore the intricacies of human development, offering a unique perspective on the fundamental mechanisms that regulate this process. Our research has the potential to reveal critical insights into developmental disorders and infertility, paving the way for innovative fertility treatments.

Learn More

Unravelling the Impact of Nutrients on Stem Cells and Cell Fate Decisions

UNRAVELLING THE IMPACT OF NUTRIENTS ON STEM CELLS AND CELL FATE DECISIONS

We explore how nutrients that vary with diet regulate stem cells and cell fate decisions during differentiation and cellular reprogramming. Our goal is to define dietary alterations that enable more accurate models of differentiation in the culture dish, to enhance rejuvenation processes with nutrients, and to lead to new treatments of pregnancy complications and various diseases.

Learn More

Disease Mechanisms

DISEASE MECHANISMS

We map disease processes and identify pathways that contribute to diseases, with the aim of developing targeted therapies and treatments. For instance, working with the Gomperts lab at UCLA, we aim to understand various diseases of the lung.

Learn More

Inventing New Technologies

INVENTING NEW TECHNOLOGIES

We create innovative single-cell omics technologies and computational methods essential for advancing our understanding of biology. For example, in collaboration with Dino Di Carlo at UCLA, we developed the Sec-seq method, which simultaneously profiles the transcriptomes and secretomes of thousands of individual cells.

Learn More

Funding

Our lab is supported by funding from the NIH, CIRM, private foundations, the UCLA Jonsson Comprehensive Cancer Center, and the UCLA Broad Stem Cell Center.

OUR TEAM

People

Marie Clemot

Project Scientist

Justin Langerman

Project Scientist

Yu (Sammy) Sun

Project Scientists
View More
OUR WORKS

Publications

RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding

Zacco E, Broglia L, Kurihara M, Monti M, Gustincich S, Pastore A, Plath K, Nagakawa S, Cerase A, Sanchez de Groot N and Tartaglia GG.
RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding.
(2024) Chem Reviews, 124:4734-4777.

Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq

Udani S, Langerman J, Koo D, Baghdasarian S, Cheng B, Kang S, Soemardy C, de Rutte J, Plath K* and Di Carlo D*. (2024).
Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq.
Nature Nanotechnology. 19:354-363. *corresponding authors.

Optimization of RNA Pepper Sensors for the Detection of Arbitrary RNA Targets

Tang AA, Afasizheva A, Cano CT, Plath K, Black D and Franco E. (2024).
Optimization of RNA Pepper Sensors for the Detection of Arbitrary RNA Targets.
ACS Synth Biology, 13:498-508.

View More
NEWS

Get the latest

Explore the latest in our field.

View More

We're Hiring

Join our team to research stem cells and their regulation, developmental decisions, and reprogramming, with a dedicated focus on female biology.

Apply Now